Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats

Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which largely associated with an increased risk developing malignant diseases cardiovascular disease. Search for new drugs, including those exhibiting pronounced antiarrhythmic activity, supposed relevance. Objective. To study effect combination therapy fabomotizole and ALM-802 on atrial depolarization a translational model alcoholic rats. Methods. The sequence epicardium was studied rats cardiomyopathy, received compound daily 28 days after end 24 weeks alcoholization, or pyrogen-free water intraperitoneally. Results. As result 28-day combined action animals additional areas early activation area lacunae pulmonary veins that form during 24-week period alcoholization disappear, arrhythmias minimized, sequential propagation.